Menopausal Hormonal Therapy And Cancer Risk
People with a uterus should use estrogen progesterone to prevent endometrial cancer. Again, these breast cancer data are based on the WHI study which mainly examined people over 60 with synthetic oral hormones. Now we encourage patients to start younger, stop earlier, consider using bio-identical hormones and consider using non-oral routes. The E3N cohort in France indicates that they have conducted a longer study that doubled the number of cases analyzed. They compared the use of synthetic estrogens / progestinene with the use of bio-identical estrogens / progesterone and again found that the use of synthetic substances significantly increased the risk of breast cancer. An important finding suggested that the use of estrogen and progesterone together was much safer than estrogen therapy alone.
Estimates of sales of bulk hormones for composition suggest that more than a million women can use BHT connection in the US. USA That is expected Bio-identical hormones have the same risks as conventional hormones made with the same categories of hormones. For many men and women suffering from the unwanted symptoms of hormonal imbalance, menopause or andropause, bioidentical hormone replacement therapy can change lives.
The North American Menopause Society has stated that compound bio-identical hormones are not approved by the FDA; There is no guarantee of purity, potency, efficacy or safety and they may contain unknown contaminants. The Australian Society of Menopause has similarly stated that there is no evidence that bio-identical hormones administered by the pill are safer than their approved counterparts. The International Society of Menopause has stated that “there are no medical or scientific Bioidentical Hormone Replacement Therapy reasons to recommend unregistered ‘bioidenthic hormones’.”. These “personalized” hormonal preparations have not been tested in studies and their purity and risks are unknown.” The FDA requires manufacturers of FDA-approved products containing estrogen and progesterone to use class labels that reflect the findings of the WHI. However, because composite preparations are not FDA approved and have no official labeling, they are exempt from including contraindications and warnings.
Santoro and Pinkerton regularly come across patients who ask for compound bio-identical hormones, often because they fear traditional hormone therapy. According to a scientific explanation from the endocrine society, patients should be advised on the risks of adapted composite bio-identical hormones. Another large-scale study of hormones and their effect on breast cancer has been completed in France. This study, called E3N Cohort, was made to compare different hormone replacement therapies and the risk of breast cancer. As in the American study, the use of synthetic estrogens and the risks of progestogenic hormones were significant for breast cancer. The risk of hormone replacement therapy is so great that the combination of synthetic HRT is considered to be a carcinogen for breast cancer.
Like supplements, which are not regulated by the FDA, the FDA’s lack of oversight of compound hormones has some providers who distrust the additional risks related to the purity and safety of custom composite bio-identical hormones. As we age, our body starts to release fewer hormones, which can lead to a variety of unpleasant symptoms such as fatigue, headache, hot flashes, weight gain and more. However, you may have heard of the risks of taking hormonal replacements such as Prempro or Premarin, so you are only dealing with symptoms.
Progesterone is approved for use by both the FDA and Health Canada as a brand of oral preparation. The French epidemiological study Etude Epidemiologique aupres de femmes de l’Education Nationale suggested that micronized progesterone may present a reduced risk of breast cancer compared to other progestins, although no large-scale clinical studies have yet been conducted. A 2012 practice post published by Canadian Family Physician magazine was closed. “.There is no convincing evidence that bio-identical hormones are safer or more effective than synthetic HST. “
In addition, custom bio-identical hormones are combined based on the specific needs and levels of each patient, further improving treatment effectiveness. Although the FDA has approved some bio-identical estradiol and progesterone preparations, it has not approved composite bio-identical hormones. Bio-identical hormones are said to be safer and more effective than traditional HRT because they have a structure identical to that in the body. But these claims have not been confirmed by reputable large-scale studies.